This Cajun Chicken Pasta has a delicious cream sauce with juicy chicken, tomatoes, and cheese! You will love this easy and delicious combination of Cajun flavors!

Be sure to check out my Marry Me Chicken Pasta and Jalapeño Popper Chicken recipes next!

Cajun Chicken Pasta in a skillet with penne pasta, cream sauce, and tomatoes.

Cajun Chicken Pasta

This Cajun Chicken Pasta recipe is the best way to add some excitement to your dinner rotation! This flavorful cream sauce has the best combination of seasonings with diced tomatoes, juicy chicken, my favorite flavor enhancers, and penne pasta. This flavor profile has everything you need to keep things exciting!

Feel free to use any kind of pasta that you have on hand, and you can mix things up with different cheese combinations too! You’re going to love this recipe. Don’t miss my PRO tips below!

How to Make It

See recipe card below this post for ingredient quantities and full instructions.

Slice the chicken in half lengthwise to create 2 thinner slices. Season each side and dredge it in flour. Sear in olive oil. Set aside and let it rest for 10 minutes, then cut into strips.

Add the white wine and reduce by half. Melt the butter and add the garlic.

A plate of cooked chicken next to a skillet with wine, butter, and garlic.

Stir in the flour and cook for 1-2 minutes. Stir in the tomato paste. Combine the half and half, chicken broth, honey, hot sauce, and seasonings. Add it to the roux in small splashes, stirring continuously. Add the diced tomatoes. Bring to a gentle boil, then reduce heat to low and simmer while you boil the pasta to al dente. Stir in the cheese.

Making a Cajun Sauce with broth, cream, seasonings, and cheese.

Add the penne and stir to combine. Add the chicken and allow it to heat through. Optional: Add a little reserved pasta water if desired to control the consistency. Garnish with cilantro and serve!

Adding penne pasta and chicken to Cajun sauce in a skillet.

Pro Tips

  • Cajun Seasoning: I use McCormick Cajun Seasoning, consider using reduced or no sodium seasoning if preferred.
  • Hot Sauce: I use Frank’s Hot Sauce for this recipe.
  • Heat Level: For less heat, use just 1 tsp. of hot sauce and omit the cayenne/red pepper flakes. You can also use regular diced tomatoes instead of Rotel with green chilies.
  • Wine: Sauvignon Blanc, Chardonnay, and Pinot Grigio are great wine choices for this recipe. Chicken broth can be used if you don’t cook with wine.
  • Tomato Paste: I use tomato paste tubes to measure smaller amounts, you can store the tubes in the fridge for zero waste!
  • Cheese: Cheddar Jack, Monterey Jack, Cheddar, and Mozzarella are all great options for this, I like to use a combination of cheeses. Shred it from a block, packaged shredded cheese doesn’t melt quite as well. If using mozzarella, use low moisture/whole milk. I use Dragone brand.
  • Pasta: Any kind of pasta can be used for this recipe, tubed pasta with ridges will cling onto the sauce the best.
  • 📘 Find this recipe on page 182 of my 2nd cookbook, Let’s Eat!

Storage

  • Store in an airtight container and refrigerate for up to 3 days or freeze for up to 3 months. This does reheat fairly well.
  • Reheating this pasta in a makeshift double boiler on the stove top is the best way to restore it to its original form. 

A white bowl of Cajun Chicken Pasta with diced tomatoes and penne pasta.

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Cajun Chicken Pasta

Prep Time: 15 minutes
Cook Time: 35 minutes
Total Time: 50 minutes
5 from 44 ratings
Servings: 4 people
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This Cajun Chicken Pasta has a delicious cream sauce with juicy chicken, tomatoes, and cheese! It makes an easy dinner idea that your family will love!

Ingredients

US Customary - Metric

Chicken

  • 1 large boneless skinless chicken breast
  • 1 teaspoon Cajun seasoning
  • 2 tablespoons flour
  • 1-2 tablespoons olive oil

Pasta/Sauce

  • ½ cup dry white wine, see notes
  • 3 tablespoons butter
  • 3 cloves garlic, minced
  • 2 tablespoons flour
  • 1 tablespoon tomato paste
  • 1 ¼ cups half and half, half cream half milk
  • ¾ cups chicken broth
  • 2 teaspoons hot sauce
  • 1 teaspoon honey
  • 10 oz. Rotel tomatoes with green chilies, drained
  • ½ cup mozzarella cheese, shredded. See notes for other cheese options.
  • ½ cup cheddar cheese, shredded
  • ½ lb. penne

Seasonings

  • 1 ½ teaspoons Cajun seasoning
  • 1 teaspoon brown sugar
  • ½ teaspoon EACH: onion powder, dried basil, oregano, mustard powder
  • 1 pinch EACH: red pepper flakes, cayenne pepper

For Serving

  • Fresh Cilantro

Instructions

  • Prep Work: Combine the half and half, chicken broth, honey, hot sauce, and seasonings in a medium measuring cup with a spout and set aside. Measure remaining ingredients before beginning.
  • Place a measuring cup in the colander you’ll use to drain the pasta, this will remind you to save some of the pasta water when that step arrives.
  • Cook the Chicken: Cut the chicken in half lengthwise to create 2-3 thinner slices. Pat dry and season each side with Cajun seasoning, then sprinkle with flour and rub it into the surface of each side.
  • Heat olive oil over medium-high heat and add the chicken. Sear on each side for about 4-5 minutes, until a golden crust has developed. Set aside and let it rest for 10 minutes, then cut into strips.
  • Begin heating a pot of salted pasta water while you prepare the sauce as outlined below.
  • Add the wine to the same skillet that you used to cook the chicken and set the heat to medium. Let it reduce by half, about 3 minutes. Use a silicone spatula to “clean” the bottom of the pan while it simmers, this will add flavor to the sauce.
  • Add the butter and garlic and cook for 1 more minute. Stir in the flour and cook for 1-2 minutes. Add the tomato paste and stir to combine.
  • Add the combined half and half mixture in small splashes, stirring continuously. Bring to a gentle boil, then reduce heat to low. Add the drained tomatoes and simmer gently, (uncovered), while you cook the pasta to al dente according to package instructions. Drain once cooked and reserve 1 cup of pasta water.
  • Gradually sprinkle in the cheese over low heat, stirring continuously.
  • Add the drained pasta and stir to combine. Add the chicken and let it warm through for 2 minutes.
  • If desired, add a little pasta water. (This adds a creamy finish and helps the pasta cling onto the sauce.)
  • Sprinkle with roughly chopped cilantro and serve!

Notes

Pro Tips
  • Cajun Seasoning: I use McCormick Cajun Seasoning, consider using reduced or no sodium seasoning if preferred.
  • Hot Sauce: I use Frank's Hot Sauce for this recipe.
  • Heat Level: For less heat, use just 1 tsp. of hot sauce and omit the cayenne/red pepper flakes. You can also use regular diced tomatoes instead of Rotel with green chilies.
  • Wine: Sauvignon Blanc, Chardonnay, and Pinot Grigio are great wine choices for this recipe. Chicken broth can be used if you don’t cook with wine.
  • Tomato Paste: I use tomato paste tubes to measure smaller amounts, you can store the tubes in the fridge for zero waste!
  • Cheese: Cheddar Jack, Monterey Jack, Cheddar, and Mozzarella are all great options for this, I like to use a combination of cheeses. Shred it from a block, packaged shredded cheese doesn’t melt quite as well. If using mozzarella, use low moisture/whole milk. I use Dragone brand.
  • Pasta: Any kind of pasta can be used for this recipe, tubed pasta with ridges will cling onto the sauce the best.
  • 📘 Find this recipe on page 182 of my 2nd cookbook, Let's Eat!
Storage
  • Store in an airtight container and refrigerate for up to 3 days or freeze for up to 3 months. This does reheat fairly well.
  • Reheating this pasta in a makeshift double boiler on the stove top is the best way to restore it to its original form. 
The nutritional information provided is an estimate and is per serving. There are 4 servings in this recipe.

Nutrition

Calories: 662kcal, Carbohydrates: 63g, Protein: 30g, Fat: 31g, Saturated Fat: 16g, Polyunsaturated Fat: 2g, Monounsaturated Fat: 10g, Trans Fat: 0.4g, Cholesterol: 111mg, Sodium: 739mg, Potassium: 710mg, Fiber: 3g, Sugar: 13g, Vitamin A: 1565IU, Vitamin C: 15mg, Calcium: 306mg, Iron: 3mg
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Course: Main Course, Pasta
Cuisine: American
Author: Stephanie
This Cajun chicken pasta recipe takes just 30 minutes to make! Just like the Chili's version, it's loaded with perfectly cooked Penne that's smothered in a savory Parmesan cream sauce and topped with Blackened Cajun chicken and diced tomatoes. #pasta #cajun #cajunchicken #chicken #dinner #alfredo #parmesan #comfortfood #italianfood #chilis #copycat #penne